BY Richard Summerfield
In a deal that will bolster its respiratory biologics portfolio, British pharmaceutical firm GSK has agreed to acquire the asthma drug specialist Aiolos Bio in a deal worth up to $1.4bn.
Under the terms of the deal, GSK will pay $1bn upfront to acquire Anglo-American biopharma firm Aiolos, and up to $400m in certain success-based regulatory milestone payments, as well as tiered royalties owed to Jiangsu Hengrui Pharmaceuticals Co., Ltd., which exclusively licensed Aiolos’ AIO-001, a potentially best-in-class, long-acting antithymic stromal lymphopoietin (TSLP) monoclonal antibody which is ready to enter phase 2 clinical development for the treatment of adult patients with asthma, with potential for additional indications including chronic rhinosinusitis with nasal polyps.
The companies did not reveal when the deal is expected to close, though it is contingent on customary conditions, including applicable regulatory agency clearances under the Hart-Scott-Rodino Act in the US.
In addition to reaching a bigger population of asthma patients, GSK said AIO-001 has the potential to “redefine” the standard-of-care as it can be administered every six months. Respiratory medicines and vaccines generated around $14bn in sales for GSK in 2022.
“We have a proud heritage and deep development expertise in respiratory medicines, especially addressing diseases driven by IL-5 with high levels of eosinophils or high T2 inflammation,” said Tony Wood, chief scientific officer at GSK. “Adding AIO-001, a potentially best-in-class medicine targeting the TSLP pathway, could expand the reach of our current respiratory biologics portfolio, including to the 40 percent of severe asthma patients with low T2 inflammation where treatment options are still needed.”
“We believe that this transaction speaks to the high potential of our long-acting anti-TSLP monoclonal antibody, AIO-001,” said Khurem Farooq, chief executive of Aiolos Bio. “By uniting with GSK, a leader with decades of experience developing respiratory therapies and a shared commitment to improving patient lives, we’re confident that we can rapidly advance this therapy in the hopes of significantly reducing the treatment burden for patients.”
Aiolos was founded in 2023 and only went public in October, launching with a $245m series A round co-led by Atlas Venture, Bain Capital Life Sciences, Forbion and Sofinnova Investments.
News: GSK boosts respiratory portfolio with $1.4 bln Aiolos Bio deal